Hydrochloric Acid → 3-Methoxy-4-methylbenzyl chloride
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[CH3:11])[CH2:6]O.[ClH:12].C(OC(C)C)(C)C>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][C:10]=1[CH3:11])[CH2:6][Cl:12]参加物
5
反応条件
- 温度
- 90 °C
実験手順
A mixture of 3-methoxy-4-methylbenzylalcohol (41.61 g), conc. hydrochloric acid (125 ml) and toluene (83 ml) was stirred at 90° C. for 1 hour. After cooling, ice-water (125 ml) and diisopropyl ether (80 ml) were added to the mixture, and the organic layer was separated, and the aqueous layer was extracted with diisopropyl ether (160 ml). The combined organic layer was washed with saturated sodium hydrogen carbonate solution and brine, dried over sodium sulfate, and evaporated in vacuo to give 3-methoxy-4-methylbenzyl chloride (46.35 g) as an oil.
後処理
- temperatureAfter cooling
- customthe organic layer was separated
- extractionthe aqueous layer was extracted with diisopropyl ether (160 ml)
- washThe combined organic layer was washed with saturated sodium hydrogen carbonate solution and brine
- dry with materialdried over sodium sulfate
- customevaporated in vacuo
出典と根拠
- ORDレコード
- ord-39ffb9a30e824374a9106730e09699e4
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07166598B2
反応ノート
読み込み中…