Pyrrolidine → HCID 17964234、化合物
反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>ClCCl>[N:18]1([S:2]([C:5]2[CH:6]=[C:7]([CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:13]=2)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3])[CH2:22][CH2:21][CH2:20][CH2:19]1参加物
4
実験手順
A solution of a mixture of 3-chlorosulfonyl-5-trifluoromethylbenzoic acid (0.5 g) and pyrrolidine (0.72 ml) in dichloromethane (5 ml) was stirred at room temperature overnight. After evaporation to dryness, water (50 ml) was added to the residue and adjusted to pH 1.0 by 1N hydrochloric acid. The resulting precipitates were collected by filtration, and dried under reduced pressure at 45° C. to give 3-(pyrrolidinosulfonyl)-5-(trifluoromethyl)benzoic acid (0.514 g) as a powder.