p-Bromobenzenesulfonyl chloride → 4-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide

HRID 1375192

反応式

HRID 1375192 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.ClC1C=CC(S(Cl)(=O)=O)=CC=1.[NH2:23][C@@H:24]([C:29](O)=[O:30])[C@@H:25]([CH2:27][CH3:28])[CH3:26].CC([C@](N)(C(O)=O)C)C.CC(C1C=CC=CC=1)C(C(O)=O)N.N[C@H](C(O)=O)[C@@H](CC)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:23][C@@H:24]([CH2:29][OH:30])[C@H:25]([CH3:26])[CH2:27][CH3:28])(=[O:10])=[O:9])=[CH:4][CH:3]=1

参加物

7

反応物 6

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 73984-Chlorobenzenesulfonyl chlorideHCID 648082-Amino-3-phenylbutanoic acidHCID 76551D-IsoleucineHCID 99288Alloisoleucine, DL-HCID 7408715(S)-2-amino-2,3-dimethylbutanoic acid

生成物 1

HCID 103370674-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide

実験手順

The following compounds (Examples 33–39, Table 5) were prepared using 4-bromobenzenesulfonyl chloride, and 4-chlorobenzenesulfonyl chloride, with D-isoleucine, L-α-methyl-valine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 33. This procedure is outlined in the following Scheme.

後処理

  1. customThe following compounds (Examples 33–39, Table 5) were prepared

出典と根拠

ORDレコード
ord-584039e801454c479c6577ce1f234983
出典データセット
uspto-grants-2007_01
特許番号
US07166622B2

関連ノート

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