4-Nitroaniline → N-(4-nitrophenyl)butanamide

HRID 1375286ノート

反応式

HRID 1375286 の反応式
[N+:1]([C:4]1[CH:10]=[CH:9][C:7]([NH2:8])=[CH:6][CH:5]=1)([O-:3])=[O:2].CN1CCOCC1.[C:18](Cl)(=[O:22])[CH2:19][CH2:20][CH3:21]>C(Cl)Cl>[N+:1]([C:4]1[CH:10]=[CH:9][C:7]([NH:8][C:18](=[O:22])[CH2:19][CH2:20][CH3:21])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 74754-NitroanilineHCID 79724-MethylmorpholineHCID 8855Butyryl chloride

生成物 1

HCID 346259N-(4-nitrophenyl)butanamide収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-nitro aniline (1.01 g, 7.23 mmol) in anhydrous CH2Cl2 (20 mL) was added NMM (0.95 mL, 8.68 mmol). To the reaction mixture was added dropwise butyryl chloride (1.00 mL, 8.68 mmol) at 0° C. After stirring for 0.5 h, the reaction was extracted with CH2Cl2 (20 mL), washed with H2O (30 mL), dried over Na2SO4, and evaporated in vacuo to give N-(4-Nitrophenyl)butyramide (1.50 g, 100%) as a white solid.

後処理

  1. extractionthe reaction was extracted with CH2Cl2 (20 mL)
  2. washwashed with H2O (30 mL)
  3. dry with materialdried over Na2SO4
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-b338941525c444359085adba3475575b
出典データセット
uspto-grants-2007_01
特許番号
US07166744B2

反応ノート

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