反応式
[CH3:1][CH:2]([NH2:5])[CH2:3][CH3:4].[F:6][C:7]([F:19])([F:18])[C:8]1[CH:9]=C(CC(=O)C)[CH:11]=[CH:12][CH:13]=1.C1([C@H](N)C)C=CC=CC=1.C(O)(=O)CCCCCCC/C=C\CCCCCCCC>C(O)C(N)(CO)CO.Cl>[F:6][C:7]([F:19])([F:18])[C:8]1[CH:9]=[C:4]([CH2:3][C@H:2]([NH2:5])[CH3:1])[CH:11]=[CH:12][CH:13]=1参加物
6
実験手順
The Arthrobacter species KNK168 strain was subjected to shaking culture by using (RS)-1-methylpropylamine as an inducer for enzyme in the same manner as Example 6. The cells harvested from 1 liter culture were suspended in 1 liter of 0.1 M Tris-hydrochloric acid buffer. Thereto were added a mixture of 30 g 1-(3-trifluoromethylphenyl)-2-propanone, 18 g (R)-1-phenylethylamine, and 44 g oleic acid (pH 8.5), and the resulting mixture was reacted at 30° C. for 40 hours. After reaction, the extraction and distillation were carried out in the same manner as in Example 6, to give 19.5 g (R)-1-(3-trifluoromethylphenyl)-2-aminopropane. The optical purity was 100% ee, and the yield was 65%.
後処理
- additionThereto were added
- customthe resulting mixture was reacted at 30° C. for 40 hours
- customAfter reaction
- extractionthe extraction and distillation
出典と根拠
- ORDレコード
- ord-3db413c33efc4b09bd3d876935a32dfc
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07169592B2
関連ノート
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