トリス(ヒドロキシメチル)アミノメタン塩酸塩
Tromethamine hydrochloride
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基本情報
- CAS
1185-53-1- 標準SMILES
Cl.NC(CO)(CO)CO- InChIKey
QKNYBSVHEMOAJP-UHFFFAOYSA-N- 分子式
- C4H11NO3.ClH
- 平均分子量
- 157.59 g/mol
- 単同位体質量
- 157.05057092
名称と識別子
- 優先名称
- Tromethamine hydrochloride
- IUPAC
- 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride
- 現地名
- トリス(ヒドロキシメチル)アミノメタン塩酸塩
- 英語名
- TRIS hydrochloride
- 分子式
- C4H12ClNO3
- 分子量
- 157.6
名称と別名
1185-53-1Tris hydrochlorideTris(hydroxymethyl)aminomethane hydrochlorideTromethamine hydrochloride2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochlorideTRIS HClTris-HClTrometamol hydrochlorideTrizma hydrochlorideTromethamine HCl1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochlorideTris chloride
名称をさらに表示
トリス(ヒドロキシメチル)アミノメタン塩酸塩2-アミノ-2-(ヒドロキシメチル)-1,3-プロパンジオール·塩酸塩トリス(ヒドロキシメチル)(アミノ)メタン·塩酸塩トロメタミン·塩酸塩トリズマ塩酸塩トリス塩酸塩2-アミノ-2-(ヒドロキシメチル)-1,3-プロパンジオール塩酸塩トリメチロールアミノメタン塩酸塩2-アミノ-2-ヒドロキシメチル-1,3-プロパンジオール塩酸塩トリス, 塩酸塩, 結晶, ≧99%トリス, 塩酸塩トリス(ヒドロキシメチル)アミノメタン塩酸塩, 99+%TRIZMA® 塩酸塩トリス, 塩酸塩, 99%Tris-HCITRIS-HCL BUFFERTris-HCTRIS-HC1Tris hydrochloric acid
DTXSID4044373Tris hydrochloride bufferUNII-383V75M34EEINECS 214-684-5383V75M34E2-Amino-2-hydroxymethyl-1,3-propanediol hydrochlorideDTXCID2024373TROMETAMOL HYDROCHLORIDE [WHO-DD]
データベース識別子
- CAS
1185-53-1- PubChem CID
- 93573
- DTXSID
DTXSID4044373- ChEMBL
CHEMBL3183206- UNII
- 383V75M34E
- EC Number
- 214-684-5
物性
構造計算による物性補完中
- 極性表面積
- 86.7 Ų
- 水素結合供与体数
- 5
- 水素結合受容体数
- 4
- 回転可能結合数
- 3
- 重原子数
- 9
- 形式電荷
- 0
- 複雑度
- 54
実験および物理化学的性質
Chemical ClassesNitrogen Compounds -> Amino Alcohols, Other
Physical Description
Dry Powder; Liquid; Other Solid; Dry Powder
Hygroscopic solid; [Sigma-Aldrich MSDS]
物理化学的性質
- 融点
- 150 · 150-152 °C
- 沸点
- 225 ℃[at · 225℃[at 101 325 Pa]
- 比重(密度)
- 1.05 g/mL · 1.05 g/mL at 20 °C
- 蒸気圧
- 0 Pa · 0Pa at 20℃
- 貯蔵温度
- room temp
- 溶解性
- 2 O: · H2O: 4M at20℃、透明、無色
- 外見
- 結晶性
- 色
- 無色透明 (40% (w/w) in H2O) 溶液
- PH
- 2.5 · 2.5-4.0 (25℃, 4M in H2O)
- 酸解離定数(Pka)
- 8.1 · 8.1(at 25℃)
- 由来生物
- synthetic
- 水溶解度
- 溶ける
- BRN
- 3675235 · 3675235
- 安定性
- 安定。強力な酸化剤、塩基、湿気とは相容れない。
- 化粧品成分の機能
- 抗菌剤
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 57.2% (103 of 180) of all reports.
Warning
H315 (42.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 180 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Chemical: 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 09-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/19306
2-amino-2-(hydroxymethyl)propane-1,3-diol: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA mild eye irritant in rabbits; Not a sensitizer in experimental animals; [Sigma-Aldrich MSDS] See Tromethamine.
Hazard Classes and CategoriesSkin Irrit. 2 (42.2%)
安全と保護具
Protective Action Criteria (PAC)
18 [mg/m3]
190 [mg/m3]
1200 [mg/m3]
化学と産業
用途と製造
UsesUsed to make surface-active agents and pharmaceuticals, as an emulsifier (for cosmetic creams and lotions, mineral oil, and paraffin wax emulsions), as a biological buffer, and as an alkalizer; [ChemIDplus]
U.S. Production2023: 400,000 - <550,000 lb
Consumer UsesStabilizing agent
Industry UsesOther
General Manufacturing Information
All Other Chemical Product and Preparation Manufacturing
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride (1:1): ACTIVE
応用分野
用途緩衝液調製用。
説明Abbreviated as Tris HCl (TRIS hydrochloride), Tris (hydroxymethyl) aminomethane hydrochloride is an organic compound commonly utilized in buffer solutions such as TAE or TBE for electrophoresis gels. It boasts high solubility in water and offers utility within the pH range of 7.0-9.0.
使用Tris Hydrochloride is a buffering medium for electrophoresis, molecular biology, and cell culture applications. It may be combined with Tris Base to simplify Tris buffer preparation. Tris Hydrochloride has been incorporated in coelomic fluid and in Cortland medium to store unfertilized rainbow trout eggs. In immunohistochemistry, Tris Hydrochloride has also been used with urea as a method for antigen retrieval.
一般的な説明TRIS hydrochloride is mainly required for preparation of buffer at physiological range of 7.3 to 7.5. The prepared buffer is compatible with biological fluids. It is of importance to laboratories as a standard pH solution.
調製方法
製造方法The preparation of TRIS hydrochloride is as follows:After reacting 2-amino-1,3-propanediol (2.50 g, 27.44 mmol) and formic acid (1.26 g, 27.44 mmol) in 50 ml of water at room temperature for 3 hours, water was distilled off under reduced pressure, A liquid was obtained. By washing the obtained liquid,An ammonium formate salt (3.76 g, 27.44 mmol) was obtained as a colorless transparent liquid.
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