Thionyl Chloride → HCID 86625063、化合物

HRID 13756ノート

反応式

HRID 13756 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:20])[C:10]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([N:17]([CH3:19])[CH3:18])[CH2:13]1)[C:5](O)=[O:6].S(Cl)([Cl:23])=O>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:20])[C:10]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([N:17]([CH3:19])[CH3:18])[CH2:13]1)[C:5]([Cl:23])=[O:6]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 686902813,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

生成物 1

HCID 86625063HCID 86625063、化合物

実験手順

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid obtained in the step 4 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.

後処理

  1. customobtained in the step 4
  2. distillationwas distilled off under reduced pressure
  3. additionthe operation of adding of toluene to the residue
  4. customfollowed by azeotropic removal of thionyl chloride

出典と根拠

ORDレコード
ord-51a8e10028bf4ad2bbe3361dd4f7becc
出典データセット
uspto-grants-2010_06
特許番号
US07728131B2

反応ノート

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