Hydrochloric Acid → 3-Ethylpent-2-enoic acid

HRID 1375936

反応式

HRID 1375936 の反応式
C[O:2][C:3](=[O:10])[CH:4]=[C:5]([CH2:8][CH3:9])[CH2:6][CH3:7].[OH-].[Na+].Cl>O1CCOCC1>[CH2:6]([C:5]([CH2:8][CH3:9])=[CH:4][C:3]([OH:10])=[O:2])[CH3:7]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 588380Methyl 3-ethylpent-2-enoate

生成物 1

HCID 127483593-Ethylpent-2-enoic acid収率 90.3%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

3-ethyl pent-2-enoic acid methyl ester (200 mg, 1.4 mmol) was dissolved in dioxane (1 ml). 1N NaOH (1 ml) was added, and the mixture was left overnight at 50° C.; 1N hydrochloric acid was added (2 ml), and the compound was extracted with ethyl acetate. The organic solution was dried over sodium sulfate, filtered and the solvent was removed under reduced pressure, obtaining 162 mg of 3-ethylpent-2-enoic acid as colourless oil. Yield 90%. 1H-NMR: (CDCl3, 500 MHz) chemical shift p.p.m. 1.06–1.11 (m, 6H, CH2CH3); 2.23 (q, 2H, CH3CH2); 2.64 (q, 2H, CH3CH2); 5.65 (s, 1H, CHC(O)).

後処理

  1. extractionthe compound was extracted with ethyl acetate
  2. dry with materialThe organic solution was dried over sodium sulfate
  3. filtrationfiltered
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-2d9251327f894ff59cd3072e9db18bc0
出典データセット
uspto-grants-2007_01
特許番号
US07169890B2

関連ノート

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