Thionyl Chloride → 4-(1-Methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoyl chloride hydrochloride
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][C:9]2[CH:17]=[CH:16][C:12]([C:13](O)=[O:14])=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:4][CH2:3]1.S(Cl)([Cl:24])=O>>[ClH:24].[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([CH2:8][C:9]2[CH:17]=[CH:16][C:12]([C:13]([Cl:24])=[O:14])=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:4][CH2:3]1参加物
3
実験手順
This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 4-(1-methylpiperidin-4-ylmethyl)-3-trifluoromethylbenzoic acid obtained in the step 2 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.
後処理
- customobtained in the step 2
- distillationwas distilled off under reduced pressure
- additionthe operation of adding of toluene to the residue
- customfollowed by azeotropic removal of thionyl chloride