2-Chlorobenzothiazole → 2-Benzothiazolyl 3-piperidinopropyl ether
反応式
[N:1]1([CH2:7][CH2:8][CH2:9][O-:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Na+].Cl[C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1>O1CCCC1>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
Sodium 3-piperidinopropanolate (5 mmol) and 5 mmol of 2-chlorobenzothiazole in 20 ml of dry tetrahydrofurane were refluxed for 12 hours. The suspension was filtered and the solvent evaporated under reduced pressure. The product was crystallized with oxalic acid from diethyl ether/ethanol.
後処理
- filtrationThe suspension was filtered
- customthe solvent evaporated under reduced pressure
- customThe product was crystallized with oxalic acid from diethyl ether/ethanol
出典と根拠
- ORDレコード
- ord-a98bbd0eb38a47ea9a963177e9862ba4
- 出典データセット
- uspto-grants-2007_01
- 特許番号
- US07169928B2
反応ノート
読み込み中…