Chlorosulfonic acid → (R)-2-Butyl-2-ethylaziridine
反応式
ClS(O)(=O)=O.[NH2:6][C@:7]([CH2:14][CH3:15])([CH2:10][CH2:11][CH2:12][CH3:13])[CH2:8]O>ClC(Cl)C>[CH2:10]([C@:7]1([CH2:14][CH3:15])[CH2:8][NH:6]1)[CH2:11][CH2:12][CH3:13]参加物
4
実験手順
Chlorosulphonic acid (1 molar equivalent) was added to a solution of the product from step (f) (15 g) in dichloroethane (90 ml) at a temperature of <16° C. When addition was complete, the mixture was stirred for 2 hours at room temperature and then evaporated i vacuo. Water (60 ml) and 50% w/v aqu. NaOH (41 ml) were added and the mixture distilled at atmospheric pressure. The organic phase of the distillate was separated and dried over KOH to give a solution of the desired product (77% yield).
後処理
- additionWhen addition
- customevaporated i vacuo
- additionNaOH (41 ml) were added
- distillationthe mixture distilled at atmospheric pressure
- customThe organic phase of the distillate was separated
- dry with materialdried over KOH
出典と根拠
- ORDレコード
- ord-7064ba60fd784219b47021f146fb0653
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05663165
反応ノート
読み込み中…