Nitric Acid → 5-Nitro-4,7-dimethyl-1,3-benzodioxole

反応式

[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[C:14]2[O:13][CH2:12][O:11][C:10]=2[C:9]([CH3:15])=[CH:8][CH:7]=1>CC(OCC1C2C(=CC=CC=2)C(COC(C)=O)=C2C=1C=CC=C2)=O.C(OC(=O)C)(=O)C>[N+:1]([C:8]1[CH:7]=[C:6]([CH3:5])[C:14]2[O:13][CH2:12][O:11][C:10]=2[C:9]=1[CH3:15])([O-:4])=[O:2]

参加物

実験手順

A solution of 0.92 mL of concentrated nitric acid in 17 mL of acetic arthydride is added dropwise to a stirred solution of 2.20 g of 4,7-dimethyl-1,3-benzodioxole in 60 mL of acetic anhydride at -5° C. After 30 minutes, the mixture is poured over 100 g of crushed ice and allowed to stir for 30 minutes as a white precipitate falls out of solution. The solid is filtered, taken up in ether, dried over magnesium sulfate and concentrated under reduced pressure to afford 2.1 g of 5-nitro-4,7-dimethyl-1,3-benzodioxole.