Sodium Hydroxide → 5-(N-Methylamino)methylimidazo[5,1-b]thiazole

HRID 1376601ノート

反応式

HRID 1376601 の反応式
[CH3:1][N:2]([CH2:9][C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[CH:12][N:11]=1)C(=O)C(F)(F)F.[OH-].[Na+]>CO>[CH3:1][NH:2][CH2:9][C:10]1[N:17]2[C:13]([S:14][CH:15]=[CH:16]2)=[CH:12][N:11]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 229167005-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole

生成物 1

HCID 212624035-(N-Methylamino)methylimidazo[5,1-b]thiazole収率 109.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 394 mg (1.49 mmol) of the above-obtained 5-(N-methyl-N-trifluoroacetylamino)methylimidazo[5,1-b]thiazole in 3 ml of methanol was added 3 ml of a 10% aqueous solution of sodium hydroxide, and the mixture was stirred at room temperature for 1 hour. The methanol was distilled off under reduced pressure. The resultant was extracted three times with chloroform. The organic layer was dried over anhydrous potassium carbonate, and concentrated under reduced pressure to give 272 mg of the title compound as an oil.

後処理

  1. distillationThe methanol was distilled off under reduced pressure
  2. extractionThe resultant was extracted three times with chloroform
  3. dry with materialThe organic layer was dried over anhydrous potassium carbonate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-b23bb46eae8742218a636a1c5b8af5e5
出典データセット
uspto-grants-1997_09
特許番号
US05663162

反応ノート

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