4,6-Di-tert-butyl-5-hydroxybenzofuran → 5-Benzofuranol, 4,6-bis(1,1-dimethylethyl)-2,3-dihydro-

HRID 1376995ノート

反応式

HRID 1376995 の反応式
[C:1]([C:5]1[C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=[C:7]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:6]=1[OH:18])([CH3:4])([CH3:3])[CH3:2]>C(O)(=O)C.[Pd]>[C:1]([C:5]1[C:10]2[CH2:11][CH2:12][O:13][C:9]=2[CH:8]=[C:7]([C:14]([CH3:17])([CH3:16])[CH3:15])[C:6]=1[OH:18])([CH3:4])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 117707334,6-Di-tert-butyl-5-hydroxybenzofuran

生成物 1

HCID 108686585-Benzofuranol, 4,6-bis(1,1-dimethylethyl)-2,3-dihydro-収率 73%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

4,6-Di-tert-butyl-5-hydroxybenzofuran (6.0 g) was dissolved in acetic acid (50 ml). After addition of 10% Pd on carbon (5.0 g), the solution was stirred under a hydrogen atmosphere (4 atm.) for 15 min. After filtering off the Pd on carbon, the filtrate was concentrated under vacuum. The concentrate was purified by silica gel chromatography (10% ethyl acetate in n-hexane) to afford 4,6-di-tert-butyl-5-hydroxy-2,3-dihydrobenzofuran [4.4 g (yield, 73%)] as a colorless, fine-grained crystal.

後処理

  1. filtrationAfter filtering off the Pd on carbon
  2. concentrationthe filtrate was concentrated under vacuum
  3. customThe concentrate was purified by silica gel chromatography (10% ethyl acetate in n-hexane)

出典と根拠

ORDレコード
ord-941ad0be81d24e22b357ce133eaa3564
出典データセット
uspto-grants-1997_09
特許番号
US05663373

反応ノート

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