Thionyl Chloride → HCID 21221127、化合物

HRID 1377188ノート

反応式

HRID 1377188 の反応式
[CH3:1][C:2]1[C:9]([CH3:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH2:4]O.C1OC2C=CC(C[Cl:19])=CC=2O1.S(Cl)(Cl)=O>CCOCC>[CH3:1][C:2]1[C:9]([CH3:10])=[C:8]([O:11][CH3:12])[CH:7]=[CH:6][C:3]=1[CH2:4][Cl:19]

参加物

5

反応物 3

HCID 24386Thionyl ChlorideHCID 887131,3-Benzodioxole, 5-(chloromethyl)-HCID 43971742,3-Dimethyl-4-methoxybenzyl alcohol

生成物 1

HCID 21221127HCID 21221127、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1 g (6.016 mmol) of 2,3-dimethyl-4-methoxybenzyl alcohol (Aldrich, Steinheim, FRG) and 4.8 g of diisopropylaminomethylpolystyrene (polyhunig base, see Ex. 44a) in 21 ml of abs. ether are treated dropwise, at from 0° C. to 5° C. and over the space of approximately 25 min, with 0.482 ml of thionyl chloride. After the reaction has ended, the mixture is filtered with suction and the solvent and the excess reagent are removed. The residue, which is the desired title compound, is subjected, without purification, to further processing. TLC Rf (hexane:ethyl acetate 4:1)=0.59. IR(CH2Cl2) inter alia: 1599, 1485, 1466 und 1107 cm-1. 1H-NMR (200 MHz, CDCl3): 7.14 (d, 1H); 6.69 (d, 1H); 4.64 (s, 2H); 3.82, 2.34 and 2.18 (each s, each 3H).

後処理

  1. filtrationthe mixture is filtered with suction
  2. customthe solvent and the excess reagent are removed
  3. customis subjected, without purification, to further processing

出典と根拠

ORDレコード
ord-9149e4903598427287ac57559a58efc6
出典データセット
uspto-grants-1997_09
特許番号
US05663200

反応ノート

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