1-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-one → 1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

HRID 1377687

反応式

HRID 1377687 の反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C:15]2=[O:23])[CH2:10][CH2:9]1)C1C=CC=CC=1>[OH-].[Pd+2].[OH-].CO>[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:16][C:15]2=[O:23])[CH2:10][CH2:9]1

参加物

4

反応物 1

HCID 36559951-(1-Benzyl-piperidin-4-yl)-1,3-dihydro-indol-2-one

生成物 1

HCID 27611521-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A solution of 10 ml of methanol containing 296 mg of 1-(1-benzyl-4-piperidyl)indol-2-one was treated with 300 mg of palladium hydroxide catalyst. The resulting suspension was hydrogenated at atmospheric pressure for 60 minutes at 23° C. More catalyst was added (100 mg) and the hydrogenation was continued for 30 minutes more. The reaction mixture was filtered through Celite, concentrated and azeotropically dried with toluene to yield 217 mg of 1-(4-piperidyl)indol-2-one.

後処理

  1. additionMore catalyst was added (100 mg)
  2. waitthe hydrogenation was continued for 30 minutes
  3. filtrationThe reaction mixture was filtered through Celite
  4. concentrationconcentrated
  5. dry with materialazeotropically dried with toluene

出典と根拠

ORDレコード
ord-ee99e36bb8b24fd0801d8ba1d9469d7f
出典データセット
uspto-grants-1997_09
特許番号
US05665719

関連ノート

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