Potassium Carbonate → p-Methoxybenzamidoxime
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=C(C(F)(F)F)[O:10][N:9]=2)=[CH:4][CH:3]=1.Cl.NO.[C:20](=O)([O-])[O-].[K+].[K+]>C(O)C>[CH3:20][O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[N:9][OH:10])[NH2:12])=[CH:4][CH:3]=1参加物
5
実験手順
3-(4-hydroxyphenyl)-5-trifluoromethyl-1,2,4- oxadiazole 13.32 g (0.1 mol) 4-methoxybenzonitrile, 20.85 g (0.3 mol) of hydroxylamine hydrochloride and 41.40 g (0.3 mol) potassium carbonate was added to 400 mL absolute ethanol and refluxed 21 hours. The product was filtered and recrystallized from methanol to give 3.12 g (0.02 mol) of 4-methoxybenzamide oxime.
後処理
- temperaturerefluxed 21 hours
- filtrationThe product was filtered
- customrecrystallized from methanol
出典と根拠
- ORDレコード
- ord-39e0383f481b425b875e46ff219e02b0
- 出典データセット
- uspto-grants-1997_09
- 特許番号
- US05665763
反応ノート
読み込み中…