Sodium Hydroxide → HCID 54249109、化合物
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]([O:17]CC)=[O:16])=[C:10]3[C@@H:9]3[CH2:20][CH2:21][N:8]3[C:7](=[O:22])[C:6]=2[CH:23]=1.[OH-].[Na+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][C:14]([C:15]([OH:17])=[O:16])=[C:10]3[C@@H:9]3[CH2:20][CH2:21][N:8]3[C:7](=[O:22])[C:6]=2[CH:23]=1参加物
4
実験手順
20.8 g (62.8 mmol) of ethyl (S)-7-chloro-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylate in 250 ml of ethanol and 75 ml (75 mmol) of 1N sodium hydroxide solution were heated to reflux for 30 min. The alcohol was evaporated on a rotary evaporator. The residue was dissolved in 250 ml of water and acidified with 1N hydrochloric acid. The crystals were filtered off under suction, washed with water and dried in a vacuum. There were obtained 18.2 g (96%) of (S)-7-chloro-12,12a-dihydro-9-oxo-9H,11H-azeto[2,1-c]imidazo[1,5-a][1,4]benzodiazepine-1-carboxylic acid of m.p. 249°-250° (dec.).