Chlorosuccinimide → HCID 21753098、化合物
反応式
[CH3:1][CH:2]([NH:11][C:12]1[CH:17]=[C:16]([O:18][CH3:19])[N:15]=[CH:14][N:13]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[Cl:20]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Cl:20][C:17]1[C:12]([NH:11][CH:2]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:1])=[N:13][CH:14]=[N:15][C:16]=1[O:18][CH3:19]参加物
4
実験手順
4.0 g (0.015 mol) of 4-(2-decylamino)-6-methoxypyrimidine were refluxed for 1 hour together with 2.2 g (0.016 mol) of N-chlorosuccinimide in 25 ml of chloroform. After cooling, the mixture was extracted by stirring with 2N sodium hydroxide solution, and the organic phase was dried and concentrated. 3.8 g (84.3% of theory) of 5-chloro-4-(2-decylamino)-6-methoxypyrimidine were obtained in the form of a yellow oil.