4-Fluoroaniline → N-(4-fluorophenyl)-2-[[2-[(4-fluorophenyl)carbamoyl]phenyl]disulfanyl]benzamide

HRID 1378806

反応式

HRID 1378806 の反応式
[C:1](Cl)(=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][S:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1>ClCCl.N1C=CC=CC=1>[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][C:1](=[O:19])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8][S:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([NH:26][C:25]2[CH:27]=[CH:28][C:22]([F:21])=[CH:23][CH:24]=2)=[O:13])=[CH:24][CH:23]=1

参加物

5

反応物 2

HCID 97314-FluoroanilineHCID 881642,2'-Dithiodibenzoyl chloride

生成物 1

HCID 465337N-(4-fluorophenyl)-2-[[2-[(4-fluorophenyl)carbamoyl]phenyl]disulfanyl]benzamide収率 9.7%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

実験手順

This compound was prepared according to the general method of Example 77 using 2,2'-dithiobisbenzoyl chloride (1.00 g, 2.92 mmol) in 20 mL of dichloromethane and 4-fluoroaniline (0,657 g, 5.91 mmol) in 5 mL of pyridine. The crude product was triturated with hot ethanol-ethyl acetate mixture, filtered, and recrystallized from ethanol-DMF to yield 0.14 g of the title compound, mp 242°-244° C.

後処理

  1. customThis compound was prepared
  2. customThe crude product was triturated with hot ethanol-ethyl acetate mixture
  3. filtrationfiltered
  4. customrecrystallized from ethanol-DMF

出典と根拠

ORDレコード
ord-3b48027c873a4603a1fef81462d5da4d
出典データセット
uspto-grants-1997_09
特許番号
US05668291

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