2-Aminobenzenesulfonamide → N-(2-sulfamoylphenyl)-2-[[2-[(2-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]benzamide

HRID 1378820

反応式

HRID 1378820 の反応式
[C:1](Cl)(=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][S:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[NH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[S:28]([NH2:31])(=[O:30])=[O:29]>ClCCl.N1C=CC=CC=1>[NH2:31][S:28]([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[NH:21][C:1](=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][S:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[S:28]([NH2:31])(=[O:29])=[O:30])=[O:13])(=[O:29])=[O:30]

参加物

5

反応物 2

HCID 728942-AminobenzenesulfonamideHCID 881642,2'-Dithiodibenzoyl chloride

生成物 1

HCID 462931N-(2-sulfamoylphenyl)-2-[[2-[(2-sulfamoylphenyl)carbamoyl]phenyl]disulfanyl]benzamide収率 19.6%

試薬・触媒・溶媒 2

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒

反応条件

温度
23 °C

実験手順

This compound was prepared according to the general method of Example 77 using 2,2'-dithiobisbenzoyl chloride (2.00 g, 5.83 mmol) in 50 mL of dichloromethane and 2-aminobenzenesulfonamide (2.00 g, 11.6 mmol) in 16 mL of pyridine. The reaction mixture was stirred for 6 days at 23° C. under nitrogen atmosphere. The crude product was recrystallized from acetonitrile to yield 0.70 g of the title compound, mp 150°-151° C. (dec.).

後処理

  1. customThis compound was prepared
  2. customThe crude product was recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-a265001db38d478dbf6f6d882861cd93
出典データセット
uspto-grants-1997_09
特許番号
US05668291

関連ノート

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