Methanol → 4-Hydroxy-3-n-propylbenzenesulfonamide

HRID 1378858ノート

反応式

HRID 1378858 の反応式
[CH2:1]([C:4]1[CH:5]=[C:6]([S:11]([NH2:14])(=[O:13])=[O:12])[CH:7]=[CH:8][C:9]=1[OH:10])[CH:2]=[CH2:3].[H][H].CO.C(Cl)Cl>C(O)C.[Pd]>[OH:10][C:9]1[CH:8]=[CH:7][C:6]([S:11]([NH2:14])(=[O:12])=[O:13])=[CH:5][C:4]=1[CH2:1][CH2:2][CH3:3]

参加物

7

反応物 4

HCID 887MethanolHCID 6344DichloromethaneHCID 217087083-Allyl-4-hydroxybenzenesulfonamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 190804514-Hydroxy-3-n-propylbenzenesulfonamide収率 99.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A Parr hydrogenation flask was charged with a solution of 3.04 g (14.30 mmol) of the product of Step A dissolved in 25 mL of ethanol and 0.300 g of a 10% palladium on carbon catalyst was added. The flask was mounted in the hydrogenation apparatus, freed of air, pressurized with hydrogen (40 psig) and shaken for 15 minutes. At the end of this period TLC analysis (3% MeOH--CH2Cl2, 2 elutions) indicated that the reaction was complete and the reaction mixture was filtered and evaporated. The product was dried in vacuo to afford 3.06 g (99%) of the title compound.

後処理

  1. filtrationthe reaction mixture was filtered
  2. customevaporated
  3. customThe product was dried in vacuo

出典と根拠

ORDレコード
ord-81c63dd8bf1b461ea13c428dcbda8286
出典データセット
uspto-grants-1997_09
特許番号
US05668176

反応ノート

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