2-Fluoroethyl bromide → N1,N1-dimethyl-N2-([4-(2-fluoroethoxy)-2-methyl-2H-indazol-3-yl]sulfonyl}formamidine

反応式

[CH3:1][N:2]([CH3:19])[CH:3]=[N:4][S:5]([C:8]1[N:9]([CH3:18])[N:10]=[C:11]2[C:16]=1[C:15]([OH:17])=[CH:14][CH:13]=[CH:12]2)(=[O:7])=[O:6].[H-].[Na+].Br[CH2:23][CH2:24][F:25]>CN(C=O)C>[CH3:1][N:2]([CH3:19])[CH:3]=[N:4][S:5]([C:8]1[N:9]([CH3:18])[N:10]=[C:11]2[C:16]=1[C:15]([O:17][CH2:23][CH2:24][F:25])=[CH:14][CH:13]=[CH:12]2)(=[O:6])=[O:7]

参加物

実験手順

4.2 g (15 mmol) of N1,N1 -dimethyl-N2 -[(4-hydroxy-2-methyl-2H-indazol-3-yl)sulfonyl]formamidine was added to a suspension containing 0.6 g (15 mmol) of 60% sodium hydride in 50 ml of DMF, and the mixture was stirred at room temperature for one hour. Further, 2 g (16 mmol) of 1-bromo-2-fluoroethane was added thereto, and the mixture was stirred at room temperature for 12 hours. The mixture was poured into ice water, and the formed crystals were collected by filtration and washed with water and IPE to obtain the desired product. This product was used for the subsequent reaction without purification. Obtained amount: 3.4 g (yield: 69.5%)