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Naphthalimide → HCID 131720205、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Naphthalimide | HCID 66491 | — |
| 反応物 | N-(2-Chloroethyl)-1,8-naphthalimide | HCID 522559 | — |
| 反応物 | 4-Chloro-piperidine-1-carboxylic acid tert-butyl ester | HCID 11138624 | — |
| 反応物 | 5-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11769929 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | HCID 131720205 | HCID 131720205 | — |
反応手順
1.2 g of 2-(2-chloroethyl)-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione ("A") [obtainable by reaction of 2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione with 1,2-dichloroethane to give 2-(2-chloroethyl)-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione] and 1.0 g of 4-(5-fluoroindol-3-yl)piperidine [obtainable by reaction of N-BOC-4-chloropiperidine with 5-fluoroindole and subsequent removal of the protective group] are dissolved in 200 ml of acetonitrile and the mixture is stirred at room temperature for 8 hours. Customary working up gives 2-[2-(4-(5-fluoro-3-indolyl)piperidino)ethyl]-2,3-dihydro-1H-benz[de]isoquinoline-1,3-dione, tetrahydrate, m.p. 235°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05670511 |
| 出典データセット | uspto-grants-1997_09 |
| ORD ID | ord-0d896ffe3af942e9aaae1ec8e18598c8 |
| 出典メモ | uspto-grants-1997_09 |