Formaldehyde → N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

HRID 1379573ノート

反応式

HRID 1379573 の反応式
[CH3:1][C:2]([NH2:12])([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[CH:5]=1)[CH3:3].C=O.[C:15](=O)(O)[O-].[Na+]>>[CH2:15]=[N:12][C:2]([CH3:1])([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[C:6]([Cl:11])[CH:5]=1)[CH3:3]

参加物

4

反応物 3

HCID 712FormaldehydeHCID 516892Sodium BicarbonateHCID 111950522-(3,5-Dichlorophenyl)propan-2-amine

生成物 1

HCID 21223286N-methylene-1-methyl-1-(3,5-dichlorophenyl)ethylamine

実験手順

1-Methyl-1-(3,5-dichlorophenyl)ethylamine (7.5 g) was gradually added to formalin (37% aqueous HCHO solution) (4.6 g) at room temperature. This mixture was subjected as it is to reaction for 7 hours. A saturated sodium bicarbonate solution was added to the reaction mixture, the resultant was extracted with ether and this organic layer was washed with saturated saline solution, and then dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure to obtain 8.6 g of N-methylene-1-methyl-1-(3,5-dichloro-phenyl)ethylamine as white crystals.

後処理

  1. customis to reaction for 7 hours
  2. extractionthe resultant was extracted with ether
  3. washthis organic layer was washed with saturated saline solution
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvent was removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-52a6716a7b1e4e29b01bd2b73c8beb15
出典データセット
uspto-grants-1997_09
特許番号
US05672566

反応ノート

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