Sodium Carbonate → HCID 13292184、化合物

HRID 1380032ノート

反応式

HRID 1380032 の反応式
[CH3:1][CH:2]([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)[CH2:3]Cl.[CH3:13][C@H:14]1[O:19][C@@H:18]([CH3:20])[CH2:17][NH:16][CH2:15]1.C([O-])([O-])=O.[Na+].[Na+]>O>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([CH2:5][CH:2]([CH3:1])[CH2:3][N:16]2[CH2:15][C@H:14]([CH3:13])[O:19][C@H:18]([CH3:20])[CH2:17]2)=[CH:7][CH:8]=1

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 6415002,6-Dimethylmorpholine, cis-HCID 132921781-Bromo-4-(3-chloro-2-methylpropyl)benzene

生成物 1

HCID 13292184HCID 13292184、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

15 parts of 2-methyl-3-(4-bromophenyl)-propyl chloride and 28 parts of cis-2,6-dimethylmorpholine were stirred at 150° C. for 8 hours. The reaction mixture was cooled, poured into 100 parts of water, brought to pH 9-10 with saturated aqueous Na2CO3 solution and extracted with methylene chloride. The organic phase was dried and concentrated and the residue was distilled to give, at a boiling point of 100°-102° C./0.01 mbar, 15.8 parts of 4-[3-(4-bromophenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine of nD22 1.5265.

後処理

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with methylene chloride
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. distillationthe residue was distilled

出典と根拠

ORDレコード
ord-fbe7cbe5811a423493474572554d55dc
出典データセット
uspto-grants-1986_04
特許番号
US04579842

反応ノート

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