1-Isocyanato-4-methoxybenzene → Carbamic acid,(4-methoxyphenyl)-,1h-indol-7-yl ester

HRID 1380080

反応式

HRID 1380080 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[CH:7]2.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:19]=[C:20]=[O:21])=[CH:15][CH:14]=1>C(OCC)C.C(N(CC)CC)C>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19][C:20](=[O:21])[O:1][C:2]2[CH:3]=[CH:4][CH:5]=[C:6]3[C:10]=2[NH:9][CH:8]=[CH:7]3)=[CH:15][CH:14]=1

参加物

5

反応物 2

HCID 794431-Isocyanato-4-methoxybenzeneHCID 27376517-Hydroxyindole

生成物 1

HCID 20242122Carbamic acid,(4-methoxyphenyl)-,1h-indol-7-yl ester

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8471Triethylamine溶媒

実験手順

To a solution of 7-hydroxyindole (0.7 g.) in ethyl ether (25 ml) and triethylamine (1 ml) is added 0.8 g. 4-methoxyphenyl isocyanate (Aldrich 23860-0). The reaction is stirred for 3 days at room temperature. The solvent is removed in vacuo and the remaining oil is purified by HPLC on silica gel.

後処理

  1. customThe solvent is removed in vacuo
  2. customthe remaining oil is purified by HPLC on silica gel

出典と根拠

ORDレコード
ord-0d3d79ab1fce4551a70c6636a84fdf01
出典データセット
uspto-grants-1986_04
特許番号
US04579865

関連ノート

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