Sodium borohydride → HCID 13247648、化合物

HRID 1380308ノート

反応式

HRID 1380308 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8]2[C:9]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[N:10][CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH:6]([C:8]2[C:9]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[N:10][CH:11]=[CH:12][CH:13]=2)[OH:7])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 13247647HCID 13247647、化合物

生成物 1

HCID 13247648HCID 13247648、化合物収率 89%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

To a solution of 4.8 g of 3-(4-chlorobenzoyl)-2-(1-imidazolyl)pyridine in 35 ml of ethanol and 5 ml of water is added 0.64 g of sodium borohydride. After the mixture is stirred at room temperature for an hour, the reaction mixture is poured into water and extracted with chloroform. The chloroform is distilled off and the residue is recrystallized from toluene to give 4.3 g of α-(4-chlorophenyl)-2-(1-imidazolyl)-3-pyridinemethanol as white crystals, melting at 133°-134° C.

後処理

  1. extractionextracted with chloroform
  2. distillationThe chloroform is distilled off
  3. customthe residue is recrystallized from toluene

出典と根拠

ORDレコード
ord-2d4734a19caf4343996cb6fd5b4eb94b
出典データセット
uspto-grants-1986_04
特許番号
US04581369

反応ノート

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