Hydrochloric Acid → (E)-1-(4-Chloro-1-butenyl)-4-fluorobenzene
反応式
[CH:1]1([CH:4]([C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=2)O)[CH2:3][CH2:2]1.[ClH:13]>C(Cl)(Cl)Cl>[Cl:13][CH2:3][CH2:2]/[CH:1]=[CH:4]/[C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1参加物
4
実験手順
Dissolve 12.8 g (0.077 mole) of α-cyclopropyl-4-fluorobenzenemethanol in 60 ml of CHCl3, add 20 ml of concentrated HCl and reflux overnight. Separate the two layers, and extract the aqueous layer with methylene chloride. Combine the methylene chloride extracts with the chloroform layer and wash with saturated aqueous sodium bicarbonate, and dry over magnesium sulfate. Evaporate the organic solvents to yield the title compound.
後処理
- temperaturereflux overnight
- customSeparate the two layers
- extractionextract the aqueous layer with methylene chloride
- washwash with saturated aqueous sodium bicarbonate
- dry with materialdry over magnesium sulfate
- customEvaporate the organic solvents
出典と根拠
- ORDレコード
- ord-bb0df537d11548a2b4de398c8f1318fc
- 出典データセット
- uspto-grants-1986_04
- 特許番号
- US04581370
反応ノート
読み込み中…