2,3-Diaminopyridine → HCID 178493630、化合物

HRID 1380719

反応式

HRID 1380719 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5](O)=O.[NH2:16]C1C=CC(C(O)=O)=C(OC)C=1.N[C:29]1[C:34]([NH2:35])=[CH:33][CH:32]=[CH:31][N:30]=1>P(Cl)(Cl)(Cl)=O>[ClH:15].[CH3:1][O:2][C:3]1[CH:11]=[C:10]([S:12]([Cl:15])(=[O:14])=[O:13])[CH:9]=[CH:8][C:4]=1[C:5]1[NH:16][C:33]2=[CH:32][CH:31]=[N:30][CH:29]=[C:34]2[N:35]=1

参加物

5

反応物 3

HCID 99562,3-DiaminopyridineHCID 755994-Amino-o-anisic acidHCID 20184580HCID 20184580、化合物

生成物 1

HCID 178493630HCID 178493630、化合物

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

反応条件

温度
80 °C

実験手順

Five grams of 2-methoxy-4-chlorosulfonyl-benzoic acid (prepared from 4-amino-2-methoxy-benzoic acid via the corresponding diazonium compound) were dissolved in 400 ml of phosphorus oxychloride and heated to 80° C. for 30 minutes. Then, 3.6 gm of 2,3-diaminopyridine were added, and the mixture was refluxed for four hours. The reaction mixture was concentrated by evaporation in vacuo and re-evaporated with toluene, and the solid residue was processed further without any other purification.

後処理

  1. temperaturethe mixture was refluxed for four hours
  2. concentrationThe reaction mixture was concentrated by evaporation in vacuo
  3. customre-evaporated with toluene
  4. customthe solid residue was processed further without any other purification

出典と根拠

ORDレコード
ord-94633bad767d4d8fbfd17521349fbbb8
出典データセット
uspto-grants-1986_04
特許番号
US04582837

関連ノート

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