Methyl Isocyanate → HCID 20184542、化合物

HRID 1380764ノート

反応式

HRID 1380764 の反応式
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1.[CH3:24][N:25]=[C:26]=[O:27]>O1CCCC1>[CH3:24][NH:25][C:26]([NH:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1)=[O:27]

参加物

4

反応物 2

HCID 12228Methyl IsocyanateHCID 20184521HCID 20184521、化合物

生成物 1

HCID 20184542HCID 20184542、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

One gram (3.0 mmol) of 5-amino-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole was dissolved in 30 ml of pure tetrahydrofuran, 2.0 ml of methylisocyanate were added, and the mixture was refluxed. After 15 minutes that solvent and any excess methylisocyanate were evaporated off in vacuo, and the residue obtained was chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol).

後処理

  1. temperaturethe mixture was refluxed
  2. customany excess methylisocyanate were evaporated off in vacuo
  3. customthe residue obtained
  4. customwas chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol)

出典と根拠

ORDレコード
ord-3387be441d6e41eb8e6e0f156a070559
出典データセット
uspto-grants-1986_04
特許番号
US04582837

反応ノート

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