1-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine → 4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine

HRID 1380956ノート

反応式

HRID 1380956 の反応式
C([N:8]1[CH2:13][CH2:12][C:11]([C:26]([O:28][CH3:29])=[O:27])([N:14]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:15](=[O:17])[CH3:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H]>[Pd].C(O)(=O)C>[CH3:29][O:28][C:26]([C:11]1([N:14]([O:18][CH2:19][C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[C:15](=[O:17])[CH3:16])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:27]

参加物

5

反応物 2

HCID 233248381-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 233248214-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

A mixture of 12.45 g of 1-benzyl-4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine and 250 ml of acetic acid is hydrogenated at room temperature and pressure with 1.5 g of 10% palladium-on-charcoal catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off. The acetic acid is flash evaporated, the residue is dissolved in toulene and stirred with 10 g of anhydrous sodium carbonate. The solid is filtered and the filtrate is flash evaporated to obtain 4-methoxycarbonyl-4-(N-phenylmethoxyacetamido)piperidine.

後処理

  1. customis hydrogenated at room temperature
  2. filtrationthe catalyst is filtered off
  3. customevaporated
  4. dissolutionthe residue is dissolved in toulene
  5. filtrationThe solid is filtered
  6. customevaporated

出典と根拠

ORDレコード
ord-cbccb428274b419395cd1469a0960944
出典データセット
uspto-grants-1986_04
特許番号
US04584303

反応ノート

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