Hexane → 1H-Indole-4-carbonyl chloride

HRID 1381489ノート

反応式

HRID 1381489 の反応式
[NH:1]1[C:9]2[C:4](=[C:5]([C:10]([OH:12])=O)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.C(Cl)(=O)C([Cl:16])=O.CCCCCC>C(Cl)Cl>[NH:1]1[C:9]2[C:4](=[C:5]([C:10]([Cl:16])=[O:12])[CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

5

反応物 3

HCID 8058HexaneHCID 65578Oxalyl chlorideHCID 595229Indole-4-carboxylic acid

生成物 1

HCID 144031811H-Indole-4-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
20 °C

実験手順

32.2 g (0.2M) dry indol-4-yl carboxylic acid are suspended in 150 ml absolute methylene chloride. 26 ml (0.3M) oxalyl chloride are added to the stirred mixture at 20° over 30 minutes. Gas evolution results. The mixture is stirred for 31/2 hours at 20° C. 150 ml Hexane are added. The mixture is stirred for another 20 minutes and the resultant heading compound filtered off, washed with methylene chloride/hexane 1:1 dried at 20° in a vacuum to give beige crystals, which are used further without purification.

後処理

  1. customGas evolution results
  2. stirringThe mixture is stirred for another 20 minutes
  3. filtrationfiltered off
  4. washwashed with methylene chloride/hexane 1:1
  5. customdried at 20° in a vacuum
  6. customto give beige crystals, which
  7. customare used further without purification

出典と根拠

ORDレコード
ord-b49900100687437292c8dbfa26dbe195
出典データセット
uspto-grants-1989_02
特許番号
US04803199

反応ノート

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