Water → HCID 14838486、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][NH:12][N:11]=1.[OH-].[K+].[CH3:17]I.O>CS(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10]1[CH:14]=[CH:13][N:12]([CH3:17])[N:11]=1参加物
6
実験手順
The pyrazole from Example 5 (b) (4.0 g) was added to a mixture of crushed potassium hydroxide pellets (4.7 g) in dry dimethylsulphoxide, which had previously been stirred for 5 minutes under nitrogen at room temperature. After stirring for 0.75 hours, methyl iodide (3.1 g) was added to the red solution and stirring was maintained for a further 0.75 hours. The reaction mix was poured into water, extracted with ethyl acetate, the organic layer washed, dried, evaporated and chromatographed to give a light brown oil.
後処理
- stirringAfter stirring for 0.75 hours
- stirringstirring
- temperaturewas maintained for a further 0.75 hours
- additionThe reaction mix
- extractionextracted with ethyl acetate
- washthe organic layer washed
- customdried
- customevaporated
- customchromatographed
- customto give a light brown oil
出典と根拠
- ORDレコード
- ord-27a3ed433f4542ce95aeb5a1af5b534f
- 出典データセット
- uspto-grants-1989_02
- 特許番号
- US04803216
反応ノート
読み込み中…