2-(5-Fluoro-2,4-dinitrophenoxy)acetic acid → 7-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one

HRID 1381640ノート

反応式

HRID 1381640 の反応式
[N+:1]([C:4]1[CH:14]=[C:13]([N+:15]([O-])=O)[C:12]([F:18])=[CH:11][C:5]=1[O:6][CH2:7][C:8](O)=[O:9])([O-])=O.[H][H]>C(O)C.[Pt](=O)=O>[F:18][C:12]1[C:13]([NH2:15])=[CH:14][C:4]2[NH:1][C:8](=[O:9])[CH2:7][O:6][C:5]=2[CH:11]=1

参加物

5

反応物 2

HCID 3028912-(5-Fluoro-2,4-dinitrophenoxy)acetic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 103133897-Fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one収率 91.4%

試薬・触媒・溶媒 2

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒

実験手順

A suspension of 2,4-dinitro-5-fluorophenoxyacetic acid (0.25 g) and platinum dioxide (80 mg) in ethanol (10 ml) was subjected to catalytic reduction at room temperature under an ordinary pressure until 130 ml of hydrogen was absorbed. The reaction mixture was filtered, and the filtrate was concentrated to give 7-fluoro-6-amino-2H-1,4-benzoxazin-3(4H)-one (0.16 g; yield, 91.4%). M.P., more than 300° C.

後処理

  1. customwas absorbed
  2. filtrationThe reaction mixture was filtered
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-05e29bf0c8854d54a844653f553cc357
出典データセット
uspto-grants-1989_02
特許番号
US04803270

反応ノート

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