Potassium Carbonate → 9-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

HRID 1381765

反応式

HRID 1381765 の反応式
Cl.[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[C:2]([O:11][CH2:12][CH:13]([O:25][CH2:26][N:27]1[CH:35]=[N:34][C:33]2[C:32](=[O:36])[NH:31][C:30]([NH2:37])=[N:29][C:28]1=2)[CH2:14][O:15][C:16](=[O:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])(=[O:10])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 136332160HCID 136332160、化合物

生成物 1

HCID 1363321599-(1,3-Di-n-octanoyloxy-2-propoxymethyl)guanine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

1.0 g of 9-(1,3-di-n-octanoyloxy-2 propoxymethyl)guanine HCl suspended in 50 ml of ether is stirred with a twofold stoichiometric excess of dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 9-(1,3-di-n-octanoyloxy-2-propoxy methyl)guanine as the free base.

後処理

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-db6385784dc245b09772589e1cf94e65
出典データセット
uspto-grants-1989_02
特許番号
US04803271

関連ノート

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