m-Chloroperbenzoic acid → 2-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one

HRID 1381899ノート

反応式

HRID 1381899 の反応式
ClC1C=CC=C([C:8](OO)=[O:9])C=1.[CH3:12][C:13]1[NH:14][C:15](=[O:19])[CH2:16][S:17][CH:18]=1>CO>[CH3:8][O:9][CH:16]1[C:15](=[O:19])[NH:14][C:13]([CH3:12])=[CH:18][S:17]1

参加物

4

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 2900175-Methyl-2h-1,4-thiazin-3(4h)-one

生成物 1

HCID 143697982-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one収率 61.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

m-Chloroperbenzoic acid (28.8 g) was added dropwise to a stirred solution of 5-methyl-2H-1,4-thiazin-3(4H)-one (15 g) in methanol (300 ml) under ice-cooling and the mixture was stirred at room temperature for 1 day. After the mixture was evaporated to dryness, the residue was extracted with ethyl acetate, washed with saturated sodium bicarbonate aqueous solution and dried over anhydrous magnesium sulfate. The solvent was evaporated to dryness to give 2-methoxy-5-methyl-2H-1,4-thiazin-3(4H)-one (11.3 g, yield 61%) as pale yellow powder.

後処理

  1. temperaturecooling
  2. customAfter the mixture was evaporated to dryness
  3. extractionthe residue was extracted with ethyl acetate
  4. washwashed with saturated sodium bicarbonate aqueous solution
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated to dryness

出典と根拠

ORDレコード
ord-5a9e8f87d0e84e33951412dd4fb6b6b7
出典データセット
uspto-grants-1989_02
特許番号
US04804668

反応ノート

読み込み中…