Water → 2,2,4,4-Tetramethylpentan-3-amine

HRID 1382051ノート

反応式

HRID 1382051 の反応式
[C:1]([C:5](=[NH:10])[C:6]([CH3:9])([CH3:8])[CH3:7])([CH3:4])([CH3:3])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>CCOCC>[CH3:2][C:1]([CH3:4])([CH:5]([NH2:10])[C:6]([CH3:9])([CH3:8])[CH3:7])[CH3:3]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 27556322,2,4,4-Tetramethyl-3-pentanone ImineHCID 21226445Aluminium lithium hydride

生成物 1

HCID 131658882,2,4,4-Tetramethylpentan-3-amine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

The imine (14 g.) in dry ether (50 ml.) was added to a suspension of lithium aluminum hydride (1.7 g.) in dry ether (50 ml.). The mixture was stirred at room temperature for 24 hours, refluxed two hours and cooled. Water (1.7 ml.), 15% sodium hydroxide solution (5 ml.) and water (5 ml.) were added cautiously in succession, the mixture filtered, concentrated and the residue distilled to afford the desired amine, b.p. 79°-81° C./40 mm.

後処理

  1. temperaturerefluxed two hours
  2. temperaturecooled
  3. filtrationthe mixture filtered
  4. concentrationconcentrated
  5. distillationthe residue distilled

出典と根拠

ORDレコード
ord-9e5d213a80aa4939b02ca1993f56b0aa
出典データセット
uspto-grants-1989_02
特許番号
US04804782

反応ノート

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