Sodium borohydride → HCID 13072124、化合物

HRID 1382487ノート

反応式

HRID 1382487 の反応式
[BH4-].[Na+].[N:3]1[CH:8]=[C:7]([C:9]([C:11]([CH3:14])([CH3:13])[CH3:12])=[O:10])[CH:6]=[N:5][CH:4]=1>O.CO>[OH:10][CH:9]([C:7]1[CH:6]=[N:5][CH:4]=[N:3][CH:8]=1)[C:11]([CH3:14])([CH3:12])[CH3:13]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 136456502,2-Dimethyl-1-(pyrimidin-5-yl)propan-1-one

生成物 1

HCID 13072124HCID 13072124、化合物収率 95.1%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

1.27 g (0.034 mole) of sodium borohydride in 10 ml of water are added to 16.4 g (0.1 mole) of tert.-butyl 5-pyrimidinyl ketone in 100 ml of methanol at room temperature. The reaction mixture is stirred at room temperature for 1 hour and concentrated in vacuo, the residue is distilled in methylene chloride and the solution is concentrated again in vacuo. 15.8 g (95% of theory) of 5-(1-hydroxy-2,2-dimethyl-propyl)-pyrimidine of melting point 93°-95° C. are obtained.

後処理

  1. concentrationconcentrated in vacuo
  2. distillationthe residue is distilled in methylene chloride
  3. concentrationthe solution is concentrated again in vacuo

出典と根拠

ORDレコード
ord-75ab43c46ae04728aa62a3d858c6ecaa
出典データセット
uspto-grants-1989_02
特許番号
US04806644

反応ノート

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