2,2,2-Trifluoroacetophenone → 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene

HRID 1382633

反応式

HRID 1382633 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.[Cl-].C1([P+](C2C=CC=CC=2)(C2C=CC=CC=2)[CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)C=CC=CC=1.[O-]CC.[Na+]>C(O)C>[C:5]1([C:3]([C:2]([F:12])([F:11])[F:1])=[CH:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 99052,2,2-TrifluoroacetophenoneHCID 2723922Sodium ethoxideHCID 2733554(4-Fluorobenzyl)triphenylphosphonium chloride

生成物 1

HCID 570563672-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene収率 90%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,2,2-Trifluoroacetophenone is reacted with triphenyl-(4-fluorobenzyl)-phosphonium chloride (R. A. Jones: Australian J. Chem. 18, 903-6 (1965) in ethanol in the presence of sodium ethoxide. 2-Phenyl-3,3,3-trifluoro-1-(4-fluorophenyl)-propene is obtained with a yield of 90%; b.p.: 105°-107° C./0.2 mm Hg, m.p.: 35°-41° C.

出典と根拠

ORDレコード
ord-018a985c58db4b17bdd4b5052bf80006
出典データセット
uspto-grants-1989_02
特許番号
US04806685

関連ノート

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