Methane → 1,3-Dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
反応式
Cl[C:2]1[C:11]2[C:10](=[O:12])[N:9]([CH3:13])[C:8](=[O:14])[N:7]([CH3:15])[C:6]=2[N:5]=[CH:4][CH:3]=1.C>CO.[Pd]>[CH3:15][N:7]1[C:6]2[N:5]=[CH:4][CH:3]=[CH:2][C:11]=2[C:10](=[O:12])[N:9]([CH3:13])[C:8]1=[O:14]参加物
5
実験手順
0.34 g of Compound 1 was dissolved in 100 ml of methanol and reduced in the presence of Pd-C. Activated charcoal powder was added, and the solution was heated and filtered. The filtrate was distilled under reduced pressure and ethanol was added thereto. The resulting crude crystals were separated from the solution by the filtration and recrystallized from ethanol to give 0.24 g of 1,3-dimethylpyrido[2,3-d]pyrimidine-2,4-dione (Compound 2).
後処理
- temperaturethe solution was heated
- filtrationfiltered
- distillationThe filtrate was distilled under reduced pressure and ethanol
- additionwas added
- customThe resulting crude crystals were separated from the solution by the filtration
- customrecrystallized from ethanol
出典と根拠
- ORDレコード
- ord-673b93bf2ef044958d4e1e291895f078
- 出典データセット
- uspto-grants-1989_02
- 特許番号
- US04808587
反応ノート
読み込み中…