Sodium Chloride → 4,4-Dimethyl-6-(1-hydroxyethyl)chroman

HRID 1382909

反応式

HRID 1382909 の反応式
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[O:10][CH2:9][CH2:8][C:7]2([CH3:15])[CH3:14])(=[O:3])[CH3:2].[BH4-].[Na+].[Cl-].[Na+]>CO>[CH3:15][C:7]1([CH3:14])[C:6]2[C:11](=[CH:12][CH:13]=[C:4]([CH:1]([OH:3])[CH3:2])[CH:5]=2)[O:10][CH2:9][CH2:8]1

参加物

5

反応物 3

HCID 5234Sodium ChlorideHCID 4311764Sodium borohydrideHCID 134781601-(4,4-Dimethyl-3,4-dihydro-2H-1-benzopyran-6-yl)ethan-1-one

生成物 1

HCID 140102484,4-Dimethyl-6-(1-hydroxyethyl)chroman収率 99%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 6.0 g of 6-acetyl-4,4-dimethylchroman in 50 ml of methanol was added, all in one portion, with stirring, 3.78 g of sodium borohydride at ca. 0° C. Stirring was continued at ca. 0° C. for 1.5 hours, and then the reaction mixture was poured into 500 ml of saturated sodium chloride solution. The resulting mixture was extracted with diethyl ether, and the combined ether extracts were dried (MgSO4) and evaporated in vacuo to give 6.0 g of the title compound as an oil.

後処理

  1. customat ca. 0° C
  2. stirringStirring
  3. extractionThe resulting mixture was extracted with diethyl ether
  4. dry with materialthe combined ether extracts were dried (MgSO4)
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-752af348fc5e4b3c8d6b1a3553a906ad
出典データセット
uspto-grants-1989_02
特許番号
US04808597

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