Hydrogen Bromide → 2-[3-(Methylamino)propyl]benzthiazole dihydrobromide

HRID 1382923ノート

反応式

HRID 1382923 の反応式
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13](C)[C:14](=O)OCC1C=CC=CC=1.CCOCC.[BrH:30]>C(O)(=O)C>[BrH:30].[BrH:30].[CH3:14][NH:13][CH2:12][CH2:11][CH2:10][C:2]1[S:1][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=1

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 53819401Benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate

生成物 1

HCID 212734622-[3-(Methylamino)propyl]benzthiazole dihydrobromide収率 93.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

1.7 g (4.99 mmol) of benzyl [3-(2-benzthiazolyl)propyl]methylcarbamate are dissolved at 0° in 40% hydrogen bromide in acetic acid and stirred at room temperature for 20 hours. Thereupon, 60 ml of ether are added and, after 1.5 hours, the precipitate formed is filtered off. After washing the crystalline precipitate with ether and drying there are obtained 1.71 g (93.1%) of 2-[3-(methylamino)propyl]benzthiazole dihydrobromide, m.p. 196°-197°.

後処理

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. washAfter washing the crystalline precipitate with ether
  4. customdrying there

出典と根拠

ORDレコード
ord-42f63d39ede14e90ae2a9acd9c59d6b5
出典データセット
uspto-grants-1989_02
特許番号
US04808605

反応ノート

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