m-Chloroperbenzoic acid → 2-Sulfamoylfuro[3,2-c]pyridine-5-oxide

HRID 1382986ノート

反応式

HRID 1382986 の反応式
[S:1]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][N:9]=[CH:8][C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].ClC1C=CC=C(C(OO)=[O:22])C=1>CO.C(OCC)(=O)C>[S:1]([C:5]1[O:13][C:12]2[CH:11]=[CH:10][N+:9]([O-:22])=[CH:8][C:7]=2[CH:6]=1)(=[O:3])(=[O:4])[NH2:2]

参加物

5

反応物 2

HCID 70297m-Chloroperbenzoic acidHCID 14372124Furo[3,2-c]pyridine-2-sulfonamide

生成物 1

HCID 143721302-Sulfamoylfuro[3,2-c]pyridine-5-oxide収率 83%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a warm (40° C.) solution of 2-sulfamoylfuro[3,2-c]pyridine (2.68 g, 13.5 mmol) in methanol (30 ml) and ethyl acetate (10 ml) was added dropwise a solution of m-chloroperbenzoic acid (3.22 g, 15 mmol) in ethyl acetate (13 ml). The reaction mixture was stirred for 18 hours as product precipitated. The pure product was collected by filtration and crystallized from hot dimethyl sulfoxide by dilution with ethanol to give 2.4 g (83% yield), m.p. 247°-248° C.

後処理

  1. customprecipitated
  2. filtrationThe pure product was collected by filtration
  3. customcrystallized from hot dimethyl sulfoxide by dilution with ethanol
  4. customto give 2.4 g (83% yield), m.p. 247°-248° C.

出典と根拠

ORDレコード
ord-9e64870d66ed47cd91d6e226ac95e6d4
出典データセット
uspto-grants-1989_02
特許番号
US04808595

反応ノート

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