Sodium Hydroxide → Furo[3,2-c]pyridin-6-ylmethanol

反応式

[OH2:1].[CH3:2][C:3]1[N+:8]([O-])=[CH:7][C:6]2[CH:10]=[CH:11][O:12][C:5]=2[CH:4]=1.[OH-].[Na+]>C(OC(=O)C)(=O)C.Cl>[OH:1][CH2:2][C:3]1[N:8]=[CH:7][C:6]2[CH:10]=[CH:11][O:12][C:5]=2[CH:4]=1

参加物

反応条件

温度: 100 °C

実験手順

A mixture of 6-methylfuro[3,2-c]pyridine-N-oxide monohydrate (19.85 g, 0.119 mol) in acetic anhydride (30 mL) was heated at 100° C. for one half hour. Then the reaction mixture was diluted with 20% hydrochloric acid (100 mL) and heating was continued for one hour. The solution was cooled and made basic with sodium hydroxide solution. The product was extracted into chloroform, dried over anhydrous sodium sulfate, filtered through a pad of charcoal and evaporated. The residue was triturated with cool benzene and the crystalline product collected by filtration to give 11.36 g (64% yield), mp: 72°-74° C.