Phosphoric Acid → Hydroxylapatite (Ca5(OH)(PO4)3)

93012609/26, filed on Mar. 9, 1993 which is forming the technical background of the present invention. According to this method a suspension of calcium hydroxide is reacted with phosphoric acid in a closed multiple circuit whereby the suspension of calcium hydroxide is past through two zones. In the first zone a continuous supply of phosphoric acid in the amount necessary to reach pH=10-11 is provided. The suspension flow rate in the first zone is 0.8 m/s to 1.5 m/s and the residence time is 1.0 s to 1.5 s. In the second zone the obtained mixture is diluted by 400 to 500 times with a suspension of calcium hydroxide. The diluted mixture is returned to the first zone and the process is repeated thereby ensuring a 4 to 5 fold circulation of the complete volume of the mixture during 10 to 20 min. After the feeding of acid is terminated the obtained suspension of the product is stirred for additionally 10 to 12 min. The resulting suspension of hydroxylapatite has a concentration of 4.5% to 5.0%. Additionally, the suspension may be dried to produce solid hydroxylapatite or dehydrated by centrifugation to produce a suspension of hydroxylapatite having a concentration of 18% to 33%.

1. custom9, 1993 which is forming the technical background of the present invention
2. customis provided
3. waitthe residence time is 1.0 s to 1.5 s
4. customduring 10 to 20 min
5. customAfter the feeding of acid is terminated
6. additionthe obtained suspension of the product
7. additionThe resulting suspension of hydroxylapatite
8. customAdditionally, the suspension may be dried

ORDレコード

ord-17793924a853446891743e8f1d084a8c

出典データセット

uspto-grants-2001_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06254855B1