Diethyl Ether → HCID 54004796、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]=[CH:10][S:11][CH3:12].O=P(Cl)(Cl)Cl.[CH2:18]([O:20]CC)C.[OH-].[Na+]>CN(C)C=O.O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[CH:10][S:11][CH3:12])[CH:18]=[O:20]参加物
7
実験手順
A solution of 5.5 g of 1-methoxy-2-(2-methylsulphanyl-vinyl)-benzene in 15 ml of dimethylformamide is heated to 80° C. with 4.7 g of POCl3 for 2 hours with stirring. After cooling diethylether and water are carefully added and the mixture obtained is adjusted to pH 9 with aqueous NaOH solution (10%). The organic phase is separated off and after drying the solvent is eliminated in vacuo. Chromatography on silica gel (cyclohexane:ethyl acetate 70:30) yields 2.5 g of 2-(2-methoxyphenyl)-3-methylsulphanyl-propenal.
後処理
- additionare carefully added
- customthe mixture obtained
- customThe organic phase is separated off
- customafter drying the solvent
出典と根拠
- ORDレコード
- ord-6f07ac164f8141db9b832dddb8167273
- 出典データセット
- uspto-grants-2001_07
- 特許番号
- US06255327B1
反応ノート
読み込み中…