Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2 → N-Me-Val-N-Me-Tyr(3-tBu)-NH2

HRID 1383743ノート

反応式

HRID 1383743 の反応式
[C:1]([N:11](C)[C@H:12]([C:16]([N:18]([CH3:35])[C@H:19]([C:32]([NH2:34])=[O:33])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([C:28]([CH3:31])([CH3:30])[CH3:29])[CH:22]=1)=[O:17])[CH:13]([CH3:15])[CH3:14])(OCC1C=CC=CC=1)=O.[H][H]>CO.[OH-].[OH-].[Pd+2]>[NH:11]([CH3:1])[C@H:12]([C:16]([N:18]([CH3:35])[C@H:19]([C:32]([NH2:34])=[O:33])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([C:28]([CH3:31])([CH3:29])[CH3:30])[CH:22]=1)=[O:17])[CH:13]([CH3:15])[CH3:14]

参加物

5

反応物 2

HCID 131722751Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2HCID 178418361HCID 178418361、化合物

生成物 1

HCID 131722752N-Me-Val-N-Me-Tyr(3-tBu)-NH2

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

A mixture of Z-N-Me-Val-N-Me-Tyr(3-tBu)-NH2 (1.17 g) and 20% palladium hydroxide on carbon (0.24 g) in methanol (20 ml) was stirred at room temperature in a hydrogen atmosphere for 1 hour. The reaction mixture was filtered and washed with methanol. The solvent was distilled off under reduced pressure and the resulting residue was subjected to silica gel column chromatography (eluting solvent consisting of chloroform, methanol and aqueous ammonia at a ratio of 100:10:1) to give N-Me-Val-N-Me-Tyr(3-tBu)-NH2 in the amount of 609 mg (71%).

後処理

  1. filtrationThe reaction mixture was filtered
  2. washwashed with methanol
  3. distillationThe solvent was distilled off under reduced pressure
  4. washeluting solvent

出典と根拠

ORDレコード
ord-08eb33597ad1421e851e417f5c042a51
出典データセット
uspto-grants-2001_07
特許番号
US06255285B1

反応ノート

読み込み中…