2-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine → 2-(1,4-Dioxaspiro[4.5]decan-8-yl)pyridine

HRID 1383777ノート

反応式

HRID 1383777 の反応式
[O:1]1[C:5]2([CH2:10][CH2:9][C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)=[CH:7][CH2:6]2)[O:4][CH2:3][CH2:2]1>C(OCC)(=O)C.[Pd]>[O:1]1[C:5]2([CH2:6][CH2:7][CH:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=3)[CH2:9][CH2:10]2)[O:4][CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 211876502-(1,4-Dioxaspiro[4.5]dec-7-en-8-yl)pyridine

生成物 1

HCID 211876632-(1,4-Dioxaspiro[4.5]decan-8-yl)pyridine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 14.6 g (67.19 mmol) of 2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyridine in ethyl acetate (400 mL) was added 4.6 g of 10% palladium on carbon catalyst. The resulting suspension was then hydrogenated at ambient temperature and atmospheric pressure until all the starting material was consumed (10.5 hr). The reaction mixture was filtered through celite and the filtrate was concentrated to give the product as an oily solid.

後処理

  1. customwas then hydrogenated at ambient temperature
  2. customatmospheric pressure until all the starting material was consumed (10.5 hr)
  3. filtrationThe reaction mixture was filtered through celite
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-365e63e73c6841f0a37f97f24c639be6
出典データセット
uspto-grants-2001_07
特許番号
US06255315B1

反応ノート

読み込み中…