Hydrochloric Acid → HCID 17895490、化合物

反応式

[C:1]1([C:7]2[N:11]3[N:12]=[C:13]([O:22][CH2:23][C:24]4[N:25](COCC[Si](C)(C)C)[N:26]=[CH:27][N:28]=4)[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)=[CH:15][C:10]3=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[C:1]1([C:7]2[N:11]3[N:12]=[C:13]([O:22][CH2:23][C:24]4[NH:25][N:26]=[CH:27][N:28]=4)[C:14]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)=[CH:15][C:10]3=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

反応条件

温度: 65 °C

実験手順

The product from Example 72 Step b) (0.68 g) was suspended in ethanol (10 ml) with 2 N hydrochloric acid (21 ml) and heated at 65° C. for 5.5 h. Saturated sodium carbonate solution was added dropwise until a solid precipitated and this was collected by filtration and washed several. times with water in the sinter funnel. The solid was recrystallised from methanol to give the required product (0.245 g, m p.=248° C.). 1H NMR (360 MHz, d6-DMSO) δ 5.61 (2H, s), 7.48-7.63 (6H, m), 7.44-7.77 (2H, m), 8.40 (4H, m), 14.13 (1H, br s); MS (ES+) m/e 370 [MH]+. Anal. Found C, 65.02; H, 4.04; N, 26.35. C20H15N7O requires C, 65.03; H, 4.09; N, 26.54%.